Microbore columns (1.0 mm i.d.) are ideal for the analysis of samples of limited availability (e.g., micropurification of picomole levels of proteins/peptides). Reducing the column diameter from the standard 4.6 mm to 1.0 mm increases the mass sensitivity by 20 times. Sample components can be collected in small elution volumes (1-50 mL) for further sequence or mass analysis. Microbore offers major benefits in pharmacokinetic assays and LC/MS applications. The typical flow rate range is 10-100 mL/min., therefore specialized HPLC systems may be required for optimum column performance.Designed specifically for column selection, sample clean-up and enrichment, column programming, back-flushing and other stream switching operations. Six peripheral ports (no center port) are interconnected through a two-position rotor. Low volume flow passages (0.6 mm I.D.) minimize dead volume that can affect column switching analyses. The pressure limit is factory set at 5000 psi (350 kg/cm2), but can be adjusted to 7000 psi (490 kg/cm2). The flat-face seal is easy to adjust.a
